Medical Professionals Online

New Research Highlights At The 2010 AAO-HNSF Sunday, Sept. 26, 2010

October 08, 2017

The 2010 Annual Meeting & OTO EXPO of the American Academy of Otolaryngology - Head and Neck Surgery Foundation (AAO-HNSF), the largest meeting of ear, nose, and throat doctors in the world, convened September 26-29, 2010, in Boston, MA.

Massive Facial Trauma Following IED Blasts in Operation Iraqi Freedom (OIF)
Presenters: Nathan Salinas, MD; Joseph Brennan, MD; Mark Gibbons, MD
Time: 11: 15 am
Location: Room 206AB

Despite modern body armor, face, eye and brain injuries account for a significant percentage of improvised explosive device-related traumas sustained by United States military service members.

In a presentation at the 2010 AAO-HNSF Annual Meeting & OTO EXPO in Boston, researchers revealed a retrospective review of American military members who sustained traumatic facial injuries from improvised explosive devices and were treated at the 332nd Air Force Theater Hospital in Iraq from October 1, 2004, through September 30, 2007.

One hundred and four representative patients who sustained facial trauma from improvised explosive device blasts were reviewed, including 75 patients with facial trauma and 29 patients meeting the criteria for massive facial trauma. The forehead, cheeks, and nose were the most commonly injured facial parts in the massive facial trauma group.

Race as a Social Construct in Head and Neck Cancer Outcomes
Presenters: Maria Worsham, PhD, FACMG; George Divine, PhD; Rick Kittles, PhD
Time: 11:39 am
Location: Room 210B

Racial differences in diagnosis and prognosis outcomes in head and neck squamous cancer (HNSCC) are usually based on self-reported race, which does not allow for the critical scientific investigation of biological factors.

In a presentation at the 2010 AAO-HNSF Annual Meeting & OTO EXPO in Boston, researchers revealed that only self-reported race was associated with the stage of cancer. Stratification within the African American group by individual ancestry showed no correlation with stage or survival, suggesting that race as a risk factor for head and neck cancer outcomes are likely due to social determinants rather than biological differences.

Compliance and Quality of Life in Patients on Voice Rest
Presenters: Bernard Rousseau, PhD; Seth Cohen, MD, MPH; Amy Zeller, MS, CCC-SLP; Andrew Tritter; Gaelyn Garrett, MD
Time: 11:38 am
Location: Room 259AB

This study attempted to determine patient compliance with prescribed voice rest and to determine the impact of voice rest on quality of life (QOL).

In a presentation at the 2010 AAO-HNSF Annual Meeting & OTO EXPO in Boston, researchers revealed that self-reported compliance with voice rest recommendations was low. Given the poor patient compliance and significant impact of voice rest on voice-related QOL, further studies are warranted to examine the efficacy of voice rest, as well as factors that may contribute to patient non-compliance with voice rest recommendations.

Cochlear Implantation Using Thin Film Array Electrodes
Presenters: Kenneth Iverson, MD; Pamela Bhatti, PhD; Jessica Falcone, BS; Brian McKinnon, MD, MBA Time: 10:30 am
Location: Room 254

Current limitations in language perception may stem from an inability to provide high resolution sound input. Thin film array technology allows for a greater density of stimulating sites within the limited diameter of the scala tympani. This study examines the use of a flexible carrier to achieve adequate depth of insertion.

In a presentation at the 2010 AAO-HNSF Annual Meeting & OTO EXPO in Boston, researchers revealed ten thin film array electrodes were successfully implanted into 10 individual temporal bones via round window (5) and cochleostomy (5) approaches. Thin film array electrodes coupled with an ITD were successfully inserted into the human cochlea, with limited trauma.

Intraoperative Use of OCT in Endocrine Surgery
Presenters: William B. Armstrong, MD; Kaveh Naemi, DO; Suzanne Keel, MD; Brian Wong, MD, PhD; Jason H Kim, MD
Time: 10:46 am
Location: Room 259AB

The study attempted to determine the feasibility of optical coherence tomography (OCT) to image and identify thyroid and parathyroid glands, fat, and lymph nodes in the neck during endocrine surgery. OCT is a high resolution optical imaging modality that generates cross-sectional views. in turbid media such as living tissue, with resolution approaching that of light microscopy. OCT relies upon intrinsic differences in tissue optical properties for image contrast.

In a presentation at the 2010 AAO-HNSF Annual Meeting & OTO EXPO in Boston, researchers revealed the first study to systematically use OCT to differentiate thyroid and parathyroid glands from other structures in the neck. OCT can be used to evaluate these structures, which can be then confirmed with histopathologic evaluation via frozen or permanent sections.

PTPN13 Expression Correlates with Survival in HPV, HNSCC
Presenters: George Harris, MD; Aaron Bossler, MD, PhD
Time: 11:32 am
Location: Room 259

The human papillomavirus (HPV) oncogene E6 has been shown to perform multiple functions (p53 degradation, telomerase activation, etc.) that play a role in oncogenic transformation. Beyond known E6 functions, a recently defined mechanism that allows cellular invasion requires the E6 PDZ binding motif (PDZBM) to induce loss of a protein tyrosine phosphatase (PTPN13) in a PDZBM-dependent manner.

In a presentation at the 2010 AAO-HNSF Annual Meeting & OTO EXPO in Boston, researchers revealed that patients who develop HNSCC associated with HPV, without the additional genetic hit associated with abnormal PTPN13, have improved survival, possibly related to fewer genetic changes. Analyzing PTPN13 status in HPV-positive HNSCC may identify those patients who will have better survival, or conversely, those patients who may require additional treatment.

Source:
Mary Stewart
American Academy of Otolaryngology -- Head and Neck Surgery